β-Hairpin stabilization through an interstrand triazole bridge.
نویسندگان
چکیده
β-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the β-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive β-hairpin peptides.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 5 شماره
صفحات -
تاریخ انتشار 2012